Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM2 | O94759 | 5/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.54 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP9 | P14780 | 6/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257892 | 1.00 | TRPM2 (0.57) | TRPM2TRPA1LTB4RMAOAMAOB | |
| SCHEMBL2255104 | 0.81 | BCL2L1 (0.67) | BCL2L1BADCYP1B1MEN1KMT2A | |
| SCHEMBL2255098 | 0.81 | BCL2L1 (0.67) | BCL2L1BADCYP1B1MEN1KMT2A | |
| SCHEMBL2257660 | 0.81 | ACLY (0.49) | MEN1KMT2AHSD17B10PKM | |
| SCHEMBL2255077 | 0.78 | ACLY (0.52) | MEN1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL2256138 | 0.77 | HCAR2 (0.59) | — | |
| SCHEMBL2253800 | 0.76 | ACLY (0.50) | BCL2L1BADALDH1A1HPGDHSD17B10 | |
| SCHEMBL2274109 | 0.75 | TRPM2 (0.76) | TRPM2TRPA1LTB4RMMP1MMP2 | |
| SCHEMBL2274104 | 0.75 | TRPM2 (0.76) | TRPM2TRPA1LTB4RMMP1MMP2 | |
| SCHEMBL2269338 | 0.75 | TRPM2 (0.75) | TRPM2TRPA1LTB4RMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | claimed |
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | TRPM2 4308/4885TRPA1 4860/4885LTB4R 3731/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | TRPM2 4308/4885TRPA1 4860/4885LTB4R 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.