Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | ADA | P00813 | 2/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29202441 | 1.00 | LMNA (0.47) | LMNAMMP12ADAANPEPERAP1 | |
| SCHEMBL18114457 | 1.00 | LMNA (0.47) | LMNAMMP12ADAANPEPERAP1 | |
| SCHEMBL13619398 | 0.91 | LMNA (0.51) | LMNAMMP12ANPEPERAP1ERAP2 | |
| SCHEMBL28767958 | 0.84 | KMT2A (0.48) | LMNAMMP12ANPEPERAP1ERAP2 | |
| SCHEMBL28432031 | 0.83 | SRR (0.47) | LMNAANPEPCYP1A2CYP2D6PKM | |
| SCHEMBL28435578 | 0.83 | SRR (0.47) | LMNAANPEPCYP1A2CYP2D6PKM | |
| SCHEMBL375856 | 0.83 | SRR (0.47) | LMNAANPEPCYP1A2CYP2D6PKM | |
| SCHEMBL29144119 | 0.80 | CNR2 (0.46) | LMNAMMP12KMT2ACNR2CYP1A2 | |
| SCHEMBL29046858 | 0.80 | CPA1 (0.47) | LMNAMMP12ANPEPERAP1ERAP2 | |
| SCHEMBL29046856 | 0.80 | CPA1 (0.47) | LMNAMMP12ANPEPERAP1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2016160677-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2016-10-06 | — | — | WO | disclosed |
| US-7994326-B2 | For treatment of various forms of neurodegeneration, including that from stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease | NORTHWESTERN UNIVERSITY (US) | 2011-08-09 | — | — | US | disclosed |