Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.47 |
| ▸ | PLK1 | P53350 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22596390 | 0.91 | PLK1 (0.45) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL22595142 | 0.84 | EGFR (0.61) | EGFRPLK1 | |
| Trifluoroacetic Acid SCHEMBL22587656 | 0.83 | EGFR (0.53) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL22595152 | 0.81 | EGFR (0.49) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL22595185 | 0.80 | EGFR (0.52) | EGFRALKINSRIGF1R | |
| SCHEMBL23441888 | 0.80 | EGFR (0.61) | EGFRPLK1 | |
| SCHEMBL22595285 | 0.80 | EGFR (0.52) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL22595277 | 0.80 | EGFR (0.52) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL23442002 | 0.79 | EGFR (0.48) | EGFRPLK1ALK | |
| SCHEMBL22595685 | 0.78 | EGFR (0.53) | EGFRPLK1ALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216371-A1 | EGFR INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2020-10-29 | — | — | WO | disclosed |