Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.63 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22601539 | 0.80 | LMNA (0.66) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL22601522 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHSD17B10ALDH1A1HTT | |
| SCHEMBL14868382 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHSD17B10ALDH1A1HTT | |
| SCHEMBL3455632 | 0.78 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL382173 | 0.78 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL22601448 | 0.77 | TSHR (0.59) | SMN1; SMN2LMNAHSD17B10ALDH1A1HTT | |
| SCHEMBL22601453 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAHSD17B10ALDH1A1HTT | |
| SCHEMBL17207185 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAHSD17B10ALDH1A1HTT | |
| SCHEMBL10414745 | 0.77 | HPGD (0.74) | SMN1; SMN2LMNAALDH1A1HTTHPGD | |
| SCHEMBL3455489 | 0.76 | HPGD (0.65) | HSP90AA1HSP90AB1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | HEPAGENE THERAPEUTICS, INC. (VG) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | ATF1, ERN1, MAP3K1 | HSP90AA1 524/4885HSP90AB1 454/4885SMN1; SMN2 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.