Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.55 |
| ▸ | OXTR | P30559 | 1/20 | 0.55 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136427 | 0.79 | POLB (0.73) | TSHRALDH1A1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL28059149 | 0.78 | ALDH1A1 (0.68) | TSHRALDH1A1POLBLMNAAVPR2 | |
| SCHEMBL383818 | 0.78 | HSP90AA1 (0.61) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22601431 | 0.77 | HSP90AA1 (0.63) | TSHRALDH1A1SMN1; SMN2HTTHSD17B10 | |
| SCHEMBL3456488 | 0.76 | HPGD (0.83) | TSHRALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL14868382 | 0.76 | SMN1; SMN2 (0.71) | TSHRALDH1A1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18774001 | 0.75 | KMT2A (0.72) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29463754 | 0.75 | ALDH1A1 (0.81) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6198498 | 0.75 | ALDH1A1 (0.81) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1692046 | 0.74 | MEN1 (0.63) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | HEPAGENE THERAPEUTICS, INC. (VG) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | ATF1, ERN1, MAP3K1 | TSHR 4486/4885ALDH1A1 1908/4885SMN1; SMN2 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.