Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22601463 | 0.85 | LMNA (0.56) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL17808299 | 0.76 | ALDH1A1 (0.58) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL10145044 | 0.75 | ALDH1A1 (0.62) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL13438728 | 0.74 | SMN1; SMN2 (0.62) | KDM4EALDH1A1SMN1; SMN2TSHRPOLB | |
| SCHEMBL12169381 | 0.74 | LMNA (0.71) | KDM4EALDH1A1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL12606990 | 0.74 | KDR (0.48) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL20224125 | 0.73 | LMNA (0.45) | KDM4EHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL12793245 | 0.72 | POLB (0.88) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL10306750 | 0.72 | POLB (0.73) | KDM4EHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL171151 | 0.72 | POLB (0.73) | KDM4EHTTALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | HEPAGENE THERAPEUTICS, INC. (VG) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | ATF1, ERN1, MAP3K1 | KDM4E 1971/4885HTT 3918/4885ALDH1A1 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.