Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12757098 | 0.83 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL29955875 | 0.79 | TSHR (0.65) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL25159990 | 0.79 | TSHR (0.78) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3409012 | 0.79 | TSHR (0.65) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL29483541 | 0.79 | TSHR (0.68) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13462508 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL1459692 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL12169381 | 0.77 | LMNA (0.71) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16480610 | 0.77 | ALDH1A1 (0.73) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL711636 | 0.77 | ABL1 (0.71) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056505-A1 | Substituted Pyrazalones | BIOGEN IDEC MA INC. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056505-A1 | Substituted Pyrazalones | ACVR1, ACVRL1, TGFBR1 | SMN1; SMN2 4777/4885TSHR 1477/4885ALDH1A1 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.