Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990082 | 0.91 | ALDH1A1 (0.50) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL1374899 | 0.91 | ALDH1A1 (0.50) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL29200855 | 0.91 | ALDH1A1 (0.50) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL29200858 | 0.91 | ALDH1A1 (0.50) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL24358140 | 0.90 | TSHR (0.49) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL22601765 | 0.90 | ALDH1A1 (0.48) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL21864768 | 0.85 | ALDH1A1 (0.52) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL20299791 | 0.85 | ALDH1A1 (0.52) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL14746164 | 0.85 | KLK7 (0.43) | ALDH1A1GAAKMT2AL3MBTL1ABCB1 | |
| SCHEMBL14746163 | 0.85 | KLK7 (0.43) | ALDH1A1GAAKMT2AL3MBTL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188071-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2025-06-12 | — | — | US | disclosed |
| US-12258338-B2 | Modulators of the integrated stress response pathway | EVOTEC INTERNATIONAL GMBH (DE) | 2025-03-25 | — | — | US | disclosed |
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2023-12-07 | — | — | US | disclosed |
| CN-116761803-A | Modulators of integrated stress response pathways | 埃沃特克国际有限责任公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-4232447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220227747-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC (UK) LIMITED (GB) | 2022-07-21 | — | — | US | disclosed |
| WO-2022084447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | disclosed |
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12258338-B2 | Modulators of the integrated stress response pathway | CRHR2, CRHR1, CRH | ALDH1A1 1700/4885GAA 2561/4885CTSL 4534/4885 |
| US-20250188071-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | CRHR2, CRHR1, CRH | ALDH1A1 1700/4885GAA 2561/4885CTSL 4534/4885 |
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | CRH, AVPR1B, CRHR2 | ALDH1A1 3614/4885GAA 3152/4885CTSL 4425/4885 |
| US-20220227747-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | CRHR2, CRHR1, CRH | ALDH1A1 1700/4885GAA 2561/4885CTSL 4534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.