Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2259651 | 0.84 | LMNA (0.36) | LMNAPOLBSMN1; SMN2RORCNR1I2 | |
| SCHEMBL15857825 | 0.79 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL12364068 | 0.79 | NR1H2 (0.40) | SMN1; SMN2RORC | |
| SCHEMBL1895618 | 0.79 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL22576104 | 0.78 | OPRD1 (0.37) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL30973204 | 0.72 | POLB (0.48) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL29358874 | 0.70 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL2260715 | 0.70 | LMNA (0.49) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL30075756 | 0.69 | LMNA (0.44) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL17499915 | 0.68 | POLB (0.47) | LMNAPOLBSMN1; SMN2GBA2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829006-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-09 | — | — | US | disclosed |
| US-20110195954-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195954-A1 | NOVEL COMPOUNDS | CALCRL, CALCR, CALCA | LMNA 1729/4885POLB 2524/4885SMN1; SMN2 4305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.