Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29689584 | 1.00 | MRGPRX4 (0.60) | MRGPRX4LMNAAGERPTGDR2PPARD | |
| SCHEMBL4640545 | 0.87 | SMN1; SMN2 (0.55) | MRGPRX4LMNAPTGDR2SMN1; SMN2POLB | |
| SCHEMBL22602085 | 0.82 | MCL1 (0.60) | LMNAAGERPPARDSMN1; SMN2HSD17B10 | |
| SCHEMBL3176485 | 0.81 | LMNA (0.62) | LMNASMN1; SMN2POLBTSHRHSD17B10 | |
| SCHEMBL17896566 | 0.81 | SMN1; SMN2 (0.55) | LMNAAGERPTGDR2PPARDSMN1; SMN2 | |
| SCHEMBL22346861 | 0.80 | AGER (0.56) | LMNAAGERPPARDSMN1; SMN2TSHR | |
| SCHEMBL29689327 | 0.80 | AGER (0.56) | LMNAAGERPPARDSMN1; SMN2TSHR | |
| SCHEMBL5397033 | 0.80 | POLB (0.64) | LMNAPTGDR2PPARDSMN1; SMN2POLB | |
| SCHEMBL4640602 | 0.79 | MRGPRX4 (0.57) | MRGPRX4LMNAAGERPTGDR2PPARD | |
| SCHEMBL5543083 | 0.79 | MCL1 (0.56) | LMNAAGERPPARDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |