SCHEMBL2260182

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL12290732	0.72	NOTUM (0.57)	NOTUMCES1GAASMN1; SMN2NOX1
	SCHEMBL2259375	0.72	NOTUM (0.61)	NOTUMMAPTKDM4ERAB9AALDH1A1
	SCHEMBL9037305	0.70	P2RX7 (0.35)	NOTUMMAPTKDM4EALDH1A1AMPD2
	SCHEMBL5734705	0.69	NOTUM (0.53)	NOTUMMAPTKDM4ECES1ALDH1A1
	SCHEMBL1944443	0.69	NOTUM (0.61)	NOTUMKDM4ECES1ALDH1A1PDE5A
	SCHEMBL1908461	0.68	NOTUM (0.55)	NOTUMPDE5A
	SCHEMBL29850056	0.67	NOTUM (1.00)	NOTUMMAPTKDM4ECES1ALDH1A1
	SCHEMBL1304374	0.67	NOTUM (1.00)	NOTUMMAPTKDM4ECES1ALDH1A1
	SCHEMBL9835556	0.67	NOTUM (0.50)	NOTUMALDH1A1PDE5AMEN1KMT2A
	SCHEMBL6690377	0.67	PDE5A (0.67)	NOTUMMAPTKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.