Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.59 |
| ▸ | BTK | Q06187 | 8/20 | 0.59 |
| ▸ | ITK | Q08881 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22604799 | 0.92 | BTK (0.62) | EGFRBTKITKJAK3MAP3K7 | |
| SCHEMBL13165510 | 0.89 | BTK (0.69) | EGFRBTKITKJAK3FLT3 | |
| SCHEMBL30854787 | 0.85 | MAP3K7 (0.74) | EGFRBTKJAK3MAP3K7MAP2K1 | |
| SCHEMBL29352639 | 0.85 | MAP3K7 (0.74) | EGFRBTKJAK3MAP3K7MAP2K1 | |
| SCHEMBL93523 | 0.85 | MAP3K7 (0.74) | EGFRBTKJAK3MAP3K7MAP2K1 | |
| SCHEMBL28059266 | 0.79 | EGFR (0.77) | EGFRBTKITK | |
| SCHEMBL10127876 | 0.77 | JAK3 (0.80) | EGFRBTKITKJAK3FLT3 | |
| SCHEMBL13169978 | 0.75 | JAK3 (0.70) | EGFRBTKJAK3MAP3K7MAP2K1 | |
| SCHEMBL3696372 | 0.74 | ITK (0.60) | EGFRBTKITK | |
| SCHEMBL2352426 | 0.74 | BTK (1.00) | EGFRBTKITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020219963-A1 | METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2020-10-29 | — | — | WO | disclosed |