Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.59 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.59 |
| ▸ | GSK3A | P49840 | 3/20 | 0.59 |
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.59 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | CAMK1 | Q14012 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265197 | 0.91 | PLK4 (0.61) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2260262 | 0.91 | PLK4 (0.61) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2261136 | 0.89 | PLK4 (0.60) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2261495 | 0.89 | PLK4 (0.60) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2263953 | 0.87 | PRKAA1 (0.57) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2260312 | 0.75 | GSK3B (1.00) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL2260628 | 0.71 | GSK3B (0.64) | PLK4AURKACHEK2CDK1CDK2 | |
| SCHEMBL21983041 | 0.68 | ADRB1 (0.50) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30183146 | 0.68 | ADRB1 (0.50) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL31491090 | 0.67 | ADRB1 (0.49) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | claimed |
| EP-1902055-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | claimed |
| WO-2007006566-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2007-01-18 | — | — | WO | claimed |
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | disclosed |
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | ABBOTT GMBH & CO. KG (DE) | 2009-12-31 | — | — | US | disclosed |
| EP-1902055-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007006566-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | GSK3B, GSK3A, GYS2 | PLK4 39/4885AURKA 337/4885CHEK2 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.