Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 6/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17127620 | 0.79 | SIGMAR1 (0.39) | NMT1SIGMAR1TMEM97 | |
| SCHEMBL17127725 | 0.73 | SIGMAR1 (0.43) | NMT1SIGMAR1TMEM97 | |
| SCHEMBL17490537 | 0.70 | NMT1 (0.45) | NMT1 | |
| SCHEMBL21968826 | 0.70 | SIGMAR1 (0.37) | NMT1SIGMAR1TMEM97 | |
| SCHEMBL762265 | 0.67 | GAA (0.46) | NMT1 | |
| Hydrochloric Acid SCHEMBL28062471 | 0.65 | GAA (0.48) | NMT1 | |
| SCHEMBL16200403 | 0.64 | MC4R (0.41) | NMT1NCF1PRMT6 | |
| SCHEMBL16200064 | 0.62 | CYP2A13 (0.42) | — | |
| SCHEMBL21338445 | 0.61 | ALDH1A1 (0.48) | SIGMAR1 | |
| SCHEMBL31010105 | 0.61 | ALDH1A1 (0.48) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122353-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2020-10-28 | — | — | EP | disclosed |