Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200064 | 0.83 | CYP2A13 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16200399 | 0.83 | SIGMAR1 (0.39) | NMT1LMNAPOLBTDP1MEN1 | |
| SCHEMBL17339934 | 0.75 | NMT1 (0.41) | MC4RNMT1LMNAALDH1A1KMT2A | |
| SCHEMBL12871802 | 0.71 | GAA (0.45) | LMNAPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13184159 | 0.70 | POLB (0.39) | LMNAPOLBALDH1A1KDM4EKMT2A | |
| SCHEMBL16200059 | 0.67 | NMT1 (0.34) | NMT1LMNAPOLBALDH1A1HPGD | |
| SCHEMBL18713011 | 0.67 | MC4R (0.42) | MC4RLMNACHKACA2NCF1 | |
| SCHEMBL10030552 | 0.66 | GAA (0.56) | MC4RLMNACHKAPOLBCA2 | |
| SCHEMBL16200237 | 0.66 | MC4R (0.41) | MC4RLMNACHKAPOLBCA2 | |
| SCHEMBL22607352 | 0.64 | NMT1 (0.39) | NMT1NCF1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |