SCHEMBL2260791

SCHEMBL2260791

Cn1ncnc2c(=O)n(C)c(=O)nc1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 8/20 1.00
NPC1 O15118 5/20 1.00
POLB P06746 5/20 1.00
MAPT P10636 5/20 1.00
RAB9A P51151 5/20 1.00
GALK1 P51570 5/20 1.00
BLM P54132 5/20 1.00
NPSR1 Q6W5P4 5/20 1.00
LMNA P02545 4/20 1.00
KDM4E B2RXH2 4/20 1.00
THRB P10828 4/20 1.00
HTT P42858 4/20 1.00
RECQL P46063 4/20 1.00
KDM4A O75164 3/20 1.00
ABL1 P00519 3/20 1.00
RIN1 Q13671 3/20 1.00
DUSP3 P51452 3/20 1.00
KMT2A Q03164 3/20 1.00
SIRT1 Q96EB6 3/20 1.00
TP53 P04637 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2180986 0.70 TDP2 (1.00) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL2180811 0.66 TDP2 (0.77) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL3473947 0.66 TDP2 (0.65) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL3470636 0.66 TDP2 (0.65) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL2181779 0.65 TDP2 (1.00) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL3471248 0.65 TDP2 (0.63) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL13272699 0.65 TDP2 (0.70) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL3472993 0.64 KDM4C (1.00) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL14614428 0.64 TDP2 (0.57) KDM4CNPC1POLBMAPTRAB9A
SCHEMBL15032586 0.64 TDP2 (1.00) KDM4CNPC1POLBMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 420 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115427032-B Pharmaceutical combination and use thereof 浙江养生堂天然药物研究所有限公司 2026-05-15 CN claimed
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
US-20240342161-A1 BISBENZYLISOQUINOLINES AS CONDITIONING AGENTS FOR IMMUNE THERAPY Escend Pharmaceuticals, Inc. 2024-10-17 US claimed
CN-118652994-A Primer combination, detection method, detection product and application of detection product 深圳市宝安区疾病预防控制中心(深圳市宝安区卫生检验中心、深圳市宝安区职业病防治所) 2024-09-17 CN claimed
EP-3500686-B1 METHODS FOR DETECTING CRANIOPHARYNGIOMA AND FOR SELECTING MEDICAMENTS AND PATIENTS FOR TREATMENT QUEST DIAGNOSTICS INVEST LLC (US) 2024-01-10 EP claimed
US-20230293565-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2023-09-21 US claimed
EP-3784240-B1 WNT6 AS GLIOBLASTOMA ONCOGENIC BIOMARKER, AND USES OF INHIBITORS THEREOF FOR TREATING WNT6-OVEREXPRESSING GLIOBLASTOMA UNIV DO MINHO (PT) 2023-09-20 EP claimed
CN-116249520-A Blocking replication of SARS-COV-2 and other pathogenic viruses using WNT/beta-catenin pathway inhibitors 阿尔伯塔大学理事会 2023-06-09 CN claimed
EP-4188378-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES The Governors of the University of Alberta (CA) 2023-06-07 EP claimed
US-20230049309-A1 CATHETER DEVICE FOR RELEASING PHARMACEUTICALLY ACTIVE COMPOUNDS OVER AN EXTENDED PERIOD CIRLO GMBH (DE) 2023-02-16 US claimed
CN-105974018-B Method based on Multifunctional cleanup column-high performance liquid chromatography detection sitotoxismus flavine 浙江省产品质量安全检测研究院 2018-06-12 CN claimed
CN-105319313-B Liquid chromatogram-tandem mass spectrum detection method of toxoflavin 山东出入境检验检疫局检验检疫技术中心 2017-02-01 CN claimed
CN-106018659-A Method for quick detection of toxoflavin in food 浙江省质量检测科学研究院 2016-10-12 CN claimed
CN-105974018-A Method for detecting toxoflavin in foodstuff based on multifunctional purifying column-high performance liquid chromatography 浙江省质量检测科学研究院 2016-09-28 CN claimed
CN-105319313-A Liquid chromatogram-tandem mass spectrum detection method of toxoflavin SHANDONG TECHNICAL CT INSPECTION & QUARANTINE 2016-02-10 CN claimed
US-20100269215-A1 Tfla gene which can degrade toxoflavin and its chemical derivatives and transgenic organisms expressing tfla gene SNU R&DB FOUNDATION (KR) 2010-10-21 US claimed
CN-101578360-A tflA gene which can degrade toxoflavin and its chemical derivatives and transgenic organisms expressing tflA gene SEOUL NAT UNIV IND FOUNDATION (KR) 2009-11-11 CN claimed
EP-2029723-A1 TFLA GENE WHICH CAN DEGRADE TOXOFLAVIN AND ITS CHEMICAL DERIVATIVES AND TRANSGENIC ORGANISMS EXPRESSING TFLA GENE SNU R&DB Foundation (KR) 2009-03-04 EP claimed
WO-2007148926-A9 TFLA GENE WHICH CAN DEGRADE TOXOFLAVIN AND ITS CHEMICAL DERIVATIVES AND TRANSGENIC ORGANISMS EXPRESSING TFLA GENE SNU R&DB FOUNDATION (KR) 2009-01-29 WO claimed
WO-2007148926-A1 TFLA GENE WHICH CAN DEGRADE TOXOFLAVIN AND ITS CHEMICAL DERIVATIVES AND TRANSGENIC ORGANISMS EXPRESSING TFLA GENE SNU R & DB FOUNDATION (KR) 2007-12-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240342161-A1 BISBENZYLISOQUINOLINES AS CONDITIONING AGENTS FOR IMMUNE THERAPY NFATC1, CTNNB1, CAMK1D KDM4C 1037/4885NPC1 4115/4885POLB 1452/4885
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES WNT3A, GSK3B, GSK3A KDM4C 1734/4885NPC1 4688/4885POLB 2105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.