Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 15/20 | 0.65 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | GALK1 | P51570 | 4/20 | 0.65 |
| ▸ | BLM | P54132 | 4/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | ABL1 | P00519 | 3/20 | 0.65 |
| ▸ | RIN1 | Q13671 | 3/20 | 0.65 |
| ▸ | RAF1 | P04049 | 3/20 | 0.65 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MPI | P34949 | 2/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.65 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.65 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24989323 | 0.84 | TDP2 (0.58) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2180986 | 0.79 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL3470636 | 0.73 | TDP2 (0.65) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2180811 | 0.73 | TDP2 (0.77) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL13272699 | 0.72 | TDP2 (0.70) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL3471248 | 0.72 | TDP2 (0.63) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL3472625 | 0.71 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL15032586 | 0.71 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL24988965 | 0.70 | TDP2 (0.45) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2183740 | 0.69 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | claimed |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
| EP-4129282-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | TCF4, TCF7L2, CTNNB1 | TDP2 2515/4885KDM4C 2237/4885NPC1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.