Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 18/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626097 | 0.78 | GLP1R (0.35) | — | |
| SCHEMBL23833558 | 0.70 | LMNA (0.43) | TNNI3KCA12CA1CA2CA3 | |
| SCHEMBL21853322 | 0.70 | ITGB1 (0.38) | LMNA | |
| SCHEMBL14322867 | 0.69 | TNNI3K (0.74) | TNNI3KBRAF | |
| SCHEMBL15392663 | 0.68 | CA12 (0.50) | TNNI3KCA12CA1CA2CA3 | |
| SCHEMBL14323857 | 0.67 | TNNI3K (0.74) | TNNI3KBRAF | |
| SCHEMBL14620825 | 0.67 | CA12 (0.36) | TNNI3KCA12CA1CA2CA3 | |
| SCHEMBL8370571 | 0.67 | KDM4E (0.53) | CA12CA1CA2CA3CA4 | |
| SCHEMBL29273586 | 0.65 | CA12 (0.52) | TNNI3KCA12CA1CA2CA3 | |
| SCHEMBL427939 | 0.65 | CA12 (0.52) | TNNI3KCA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3732176-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2020-11-04 | — | — | EP | disclosed |