Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833535 | 0.79 | L3MBTL1 (0.41) | LMNAKMT2AGAAALDH1A1MEN1 | |
| SCHEMBL3019043 | 0.79 | ALDH1A1 (0.34) | KMT2AGAAALDH1A1MEN1HTT | |
| SCHEMBL30094575 | 0.79 | L3MBTL1 (0.41) | LMNAKMT2AGAAALDH1A1MEN1 | |
| SCHEMBL23833619 | 0.79 | ALDH1A1 (0.47) | LMNAKMT2AGAAALDH1A1MEN1 | |
| SCHEMBL23833649 | 0.78 | PDIA6 (0.41) | LMNAALDH1A1CA12CA1CA2 | |
| SCHEMBL30096955 | 0.78 | PDIA6 (0.41) | LMNAALDH1A1CA12CA1CA2 | |
| SCHEMBL23833645 | 0.78 | CYP3A4 (0.49) | LMNAKMT2AALDH1A1CA12CA1 | |
| SCHEMBL23845694 | 0.76 | CDK1 (0.34) | KMT2AGAAALDH1A1HTTKDM4E | |
| SCHEMBL26608096 | 0.75 | TSHR (0.45) | LMNAKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL30858406 | 0.74 | POLB (0.41) | LMNAKMT2AALDH1A1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121426-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | Akebia Therapeutics Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021188938-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |