Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25239960 | 0.80 | KIT (0.46) | BRAFKITDDR1 | |
| SCHEMBL25124396 | 0.78 | BRAF (0.42) | BRAFKITDDR1KDM4E | |
| SCHEMBL25392090 | 0.75 | NAMPT (0.45) | BRAFKITDDR1 | |
| SCHEMBL8368743 | 0.72 | ALDH1A1 (0.59) | KDRPIK3CA | |
| SCHEMBL12846720 | 0.69 | CDK2 (0.69) | PIK3CAKDM4EMAPT | |
| SCHEMBL21646384 | 0.69 | KIT (0.40) | BRAFKITDDR1MAPT | |
| SCHEMBL23560422 | 0.68 | MTNR1B (0.57) | PIK3CAMAPT | |
| SCHEMBL15196112 | 0.68 | MDM2 (0.67) | — | |
| SCHEMBL7067259 | 0.68 | TP53 (0.43) | BRAFKITDDR1 | |
| SCHEMBL10622694 | 0.67 | CDK2 (0.43) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731848-A1 | TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT | The General Hospital Corporation (US) | 2020-11-04 | — | — | EP | disclosed |