Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.41 |
| ▸ | MLYCD | O95822 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557159 | 0.75 | ALKBH2 (0.47) | KITDDR1GABRA1GABRB2HCAR3 | |
| SCHEMBL25419641 | 0.73 | LMNA (0.54) | KITDDR1SMN1; SMN2NTRK1 | |
| SCHEMBL5429491 | 0.69 | MLYCD (0.51) | TP53MLYCDHPGDEGFRERBB2 | |
| SCHEMBL28527737 | 0.69 | HTT (0.57) | TP53MLYCDHCAR3TSHRNPSR1 | |
| SCHEMBL9694832 | 0.68 | MLYCD (0.72) | TP53MLYCDHPGDEGFRERBB2 | |
| SCHEMBL9540613 | 0.68 | MLYCD (0.57) | TP53MLYCDHPGDHTR1ADRD2 | |
| SCHEMBL22609136 | 0.68 | BRAF (0.48) | KITDDR1BRAF | |
| SCHEMBL22609135 | 0.68 | KIT (0.36) | KITDDR1BRAFGABRA1GABRB2 | |
| SCHEMBL1003735 | 0.67 | TP53 (0.68) | TP53MLYCDHPGDHTR1ADRD2 | |
| SCHEMBL20355784 | 0.67 | EGFR (0.43) | MLYCDHPGDHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022890-A1 | Heterocyclic dihydropyrimidine compounds | PEDESTRIAN CONCEPTS LLC | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030022890-A1 | Heterocyclic dihydropyrimidine compounds | KCNJ2, KCNH2, KCNH1 | TP53 3832/4885KIT 2907/4885DDR1 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.