Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609364 | 0.84 | PRKAB2 (0.38) | MEN1KMT2AL3MBTL1PRKAB2PRKAG1 | |
| SCHEMBL22609390 | 0.73 | FYN (0.39) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL22609379 | 0.68 | MAPT (0.40) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL21070129 | 0.66 | SMN1; SMN2 (0.44) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL18837905 | 0.64 | PLK1 (0.63) | FYNSMN1; SMN2HTTHPGD | |
| SCHEMBL3384140 | 0.63 | PAK1 (0.58) | MEN1KMT2AYTHDC1LMNAGAA | |
| SCHEMBL27589197 | 0.63 | MAPT (0.46) | MEN1KMT2AL3MBTL1YTHDC1ALDH1A1 | |
| SCHEMBL22609500 | 0.63 | ABCC8 (0.36) | — | |
| SCHEMBL22609396 | 0.62 | MAPT (0.34) | L3MBTL1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL10153931 | 0.62 | PLK1 (0.70) | KMT2ASMN1; SMN2HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |