Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.30 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609379 | 0.85 | MAPT (0.40) | MAPTALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL166629 | 0.80 | CDC7 (0.39) | MAPTALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22609364 | 0.78 | PRKAB2 (0.38) | MAPTALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22609500 | 0.74 | ABCC8 (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL22609420 | 0.69 | ABCC8 (0.32) | ABCC8KCNJ11 | |
| SCHEMBL2911881 | 0.66 | KDM4E (0.34) | MAPTALDH1A1LMNAKDM4EPOLB | |
| SCHEMBL27807785 | 0.65 | KDM4E (0.39) | MAPTALDH1A1LMNAKDM4EPOLB | |
| SCHEMBL6365854 | 0.64 | SMN1; SMN2 (0.37) | MAPTALDH1A1KDM4EPOLBCTDSP1 | |
| SCHEMBL21070075 | 0.63 | LMNA (0.39) | MAPTALDH1A1LMNAL3MBTL1NPC1 | |
| SCHEMBL6366645 | 0.63 | ALDH1A1 (0.39) | MAPTALDH1A1KDM4EPOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |