Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21070060 | 0.84 | MAPK1 (0.44) | KCNJ1KDM4EALDH1A1KMT2AHPGD | |
| SCHEMBL21070699 | 0.82 | CHRNB2 (0.35) | KCNJ1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL31664146 | 0.82 | CHRNB2 (0.35) | KCNJ1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL21070453 | 0.77 | GABRP (0.33) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL3568441 | 0.77 | ALDH1A1 (0.54) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL6505228 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1KMT2AMAP4K4GAA | |
| SCHEMBL6470229 | 0.75 | CA9 (0.47) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL12800042 | 0.74 | IRAK4 (0.50) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL21069440 | 0.73 | NPC1 (0.43) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL21070649 | 0.72 | ALDH1A1 (0.40) | KDM4EALDH1A1KMT2AL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112105385-A | IRAK degrading agents and uses thereof | 凯麦拉医疗公司 | 2020-12-18 | — | — | CN | disclosed |
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |