Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2259210 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2260667 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2263708 | 0.80 | ALDH1A1 (0.61) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2261171 | 0.79 | ALDH1A1 (0.60) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2260544 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2260761 | 0.78 | ALDH1A1 (0.58) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL2261232 | 0.78 | ALDH1A1 (0.58) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL27766045 | 0.78 | ALDH1A1 (0.58) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL4664207 | 0.75 | ALDH1A1 (0.55) | ALDH1A1TP53KEAP1NFE2L2KMT2A | |
| SCHEMBL7591017 | 0.73 | KEAP1 (0.67) | ALDH1A1TP53KEAP1NFE2L2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460453-B | Novel sulfonamide compounds | ACTELION PHARMACEUTICALS LTD | 2012-10-03 | — | — | CN | disclosed |
| US-8003654-B2 | N-glycinsulfonamide derivatives and uses as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-23 | — | — | US | disclosed |
| US-20090275588-A1 | NOVEL SULFONAMIDE COMPOUNDS | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-11-05 | — | — | US | disclosed |
| CN-101460453-A | Novel sulfonamide compounds | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-17 | — | — | CN | disclosed |
| EP-2007717-A1 | NOVEL SULFONAMIDE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007116374-A1 | NOVEL SULFONAMIDE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275588-A1 | NOVEL SULFONAMIDE COMPOUNDS | HCRTR2, HCRTR1, NPSR1 | ALDH1A1 2824/4885TP53 4868/4885KEAP1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.