Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | EDNRB | P24530 | 1/20 | 0.56 |
| ▸ | EDNRA | P25101 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573915 | 0.84 | LMNA (0.78) | ALDH1A1LMNASMN1; SMN2HTTCA12 | |
| SCHEMBL7590717 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2ALDH1A1LMNAFFAR4 | |
| SCHEMBL18962990 | 0.80 | ALDH1A1 (0.72) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL789512 | 0.78 | KEAP1 (0.55) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL6927327 | 0.78 | LMNA (0.69) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL6563140 | 0.78 | KEAP1 (0.70) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL5955403 | 0.77 | TRIM24 (0.63) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL13633772 | 0.77 | LMNA (0.71) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL4608475 | 0.76 | LMNA (0.67) | KEAP1NFE2L2ALDH1A1TP53LMNA | |
| SCHEMBL8752463 | 0.76 | CA12 (1.00) | KEAP1NFE2L2ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |