Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612365 | 1.00 | GRM5 (0.36) | GRM5NPY5RSCN9AHCRTR1HCRTR2 | |
| SCHEMBL22622798 | 0.85 | ALDH1A1 (0.46) | — | |
| SCHEMBL31566196 | 0.84 | TIPARP (0.34) | GRM5NPY5RSCN9APDE7A | |
| SCHEMBL22612370 | 0.84 | TIPARP (0.34) | GRM5NPY5RSCN9APDE7A | |
| SCHEMBL22612368 | 0.84 | TIPARP (0.34) | GRM5NPY5RSCN9APDE7A | |
| SCHEMBL22612429 | 0.83 | AR (0.42) | — | |
| SCHEMBL22612431 | 0.83 | AR (0.42) | — | |
| SCHEMBL22612355 | 0.82 | GRM5 (0.37) | GRM5NPY5RSCN9A | |
| SCHEMBL22612358 | 0.82 | GRM5 (0.37) | GRM5NPY5RSCN9A | |
| SCHEMBL22612430 | 0.82 | ATF4 (0.46) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, IRF3 | GRM5 1089/4885NPY5R 1505/4885SCN9A 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.