Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612370 | 1.00 | TIPARP (0.34) | TIPARPNPY5RPDE7ASCN9AGRM5 | |
| SCHEMBL31566196 | 1.00 | TIPARP (0.34) | TIPARPNPY5RPDE7ASCN9AGRM5 | |
| SCHEMBL22616381 | 0.94 | TIPARP (0.32) | TIPARPNPY5RPDE7A | |
| SCHEMBL22612365 | 0.84 | GRM5 (0.36) | NPY5RPDE7ASCN9AGRM5 | |
| SCHEMBL22612362 | 0.84 | GRM5 (0.36) | NPY5RPDE7ASCN9AGRM5 | |
| SCHEMBL28523808 | 0.84 | ALDH1A1 (0.45) | — | |
| SCHEMBL29408897 | 0.84 | ALDH1A1 (0.45) | — | |
| SCHEMBL22622952 | 0.84 | ALDH1A1 (0.45) | — | |
| SCHEMBL22612360 | 0.82 | TIPARP (0.33) | TIPARPSCN9AGRM5 | |
| SCHEMBL22612357 | 0.82 | TIPARP (0.33) | TIPARPSCN9AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-05 | — | — | US | disclosed |
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | TIPARP 1582/4885NPY5R 2797/4885PDE7A 4639/4885 |
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, IRF3 | TIPARP 2891/4885NPY5R 1505/4885PDE7A 4577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.