Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 9/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Romifidine SCHEMBL22616289 | 1.00 | ADRA2A (0.46) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616243 | 0.92 | ADRA2A (0.43) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616264 | 0.92 | ADRA2A (0.43) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616132 | 0.90 | ADRA2A (0.41) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616310 | 0.89 | HTR1D (0.50) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL29761110 | 0.89 | ADRA2C (0.56) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL246009 | 0.89 | ADRA2C (0.56) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616245 | 0.88 | HTR1D (0.52) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL22616284 | 0.87 | ADRA2C (0.55) | ADRA2AADRA2CADRA2BADRA1AADRA1D | |
| Romifidine SCHEMBL1970327 | 0.87 | ADRA2C (0.57) | ADRA2AADRA2CADRA2BADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220211672-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2022-07-07 | — | — | US | disclosed |
| WO-2020222192-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2020-11-05 | — | — | WO | disclosed |