Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22618999 | 0.78 | LMNA (0.43) | LMNAPTGS1PTGS2CYP3A4CYP2C9 | |
| SCHEMBL22928009 | 0.76 | LMNA (0.61) | LMNAKMT2ASMN1; SMN2NPSR1ADRA2A | |
| SCHEMBL22619000 | 0.75 | LMNA (0.41) | LMNAKMT2APTGS1PTGS2CYP3A4 | |
| SCHEMBL7595633 | 0.73 | LMNA (0.74) | LMNAKMT2ASMN1; SMN2NPSR1TSHR | |
| SCHEMBL22618989 | 0.72 | HPGD (0.43) | LMNAKMT2ASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL22618998 | 0.72 | CYP19A1 (0.43) | LMNAKMT2APTGS1PTGS2TSHR | |
| SCHEMBL15314389 | 0.72 | KMT2A (0.65) | KMT2ASMN1; SMN2PTGS1PTGS2TSHR | |
| SCHEMBL22619045 | 0.71 | HTR6 (0.46) | KMT2APTGS1PTGS2HTR6MEN1 | |
| SCHEMBL22619087 | 0.71 | EDNRA (0.44) | LMNAKMT2APTGS1PTGS2CYP3A4 | |
| SCHEMBL1975871 | 0.71 | LMNA (0.54) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |