Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22928030 | 0.80 | BRS3 (0.44) | EDNRAKMT2APOLBCYP3A4LMNA | |
| SCHEMBL22619083 | 0.78 | PARP1 (0.45) | POLBLMNAITGA1HTR6CYP19A1 | |
| SCHEMBL22619084 | 0.74 | ITGA1 (0.36) | PTGS1PTGS2KMT2AITGA1HTR6 | |
| SCHEMBL15314389 | 0.72 | KMT2A (0.65) | PTGS1PTGS2KMT2APOLBGAA | |
| SCHEMBL22618998 | 0.72 | CYP19A1 (0.43) | PTGS1PTGS2KMT2APOLBLMNA | |
| SCHEMBL22618989 | 0.72 | HPGD (0.43) | PTGS1PTGS2KMT2ALMNAITGA1 | |
| SCHEMBL22619002 | 0.71 | LMNA (0.71) | PTGS1PTGS2KMT2APOLBCYP3A4 | |
| SCHEMBL22619088 | 0.71 | PTGS1 (0.38) | PTGS1PTGS2KMT2ACYP3A4TDO2 | |
| SCHEMBL2690296 | 0.70 | KEAP1 (0.66) | KMT2APOLBLMNAITGA1HTR6 | |
| SCHEMBL22619001 | 0.70 | PFKFB3 (0.41) | PTGS1PTGS2PFKFB3KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |