Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 3/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597856 | 0.81 | MEN1 (0.41) | MEN1KMT2AUCHL1HIF1ACA2 | |
| SCHEMBL28870982 | 0.80 | MEN1 (0.40) | MEN1KMT2AUCHL1HIF1ACA2 | |
| SCHEMBL28665821 | 0.80 | MEN1 (0.40) | MEN1KMT2AUCHL1HIF1ACA2 | |
| SCHEMBL28604770 | 0.75 | ALDH1A1 (0.39) | MEN1KMT2ACA2CA1CA9 | |
| SCHEMBL23043778 | 0.75 | HSD17B3 (0.37) | MEN1KMT2AUCHL1HIF1AROCK1 | |
| SCHEMBL2730662 | 0.75 | CA1 (0.58) | HIF1ACA2CA1CA9F11 | |
| SCHEMBL23795687 | 0.74 | UCHL1 (0.41) | MEN1KMT2AUCHL1HIF1ACA2 | |
| SCHEMBL28607887 | 0.74 | UCHL1 (0.41) | MEN1KMT2AUCHL1CA2CA1 | |
| SCHEMBL5761327 | 0.73 | MEN1 (0.54) | MEN1KMT2AHIF1ACA2CA1 | |
| SCHEMBL19125562 | 0.73 | LIPG (0.45) | UCHL1HIF1AF11ROCK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |