Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235287 | 0.83 | GRM2 (0.46) | HTR6TDP1KDM4EALDH1A1RAB9A | |
| SCHEMBL2117424 | 0.80 | HTR6 (0.48) | HTR6ALDH1A1TSHRMAPTKMT2A | |
| SCHEMBL4384076 | 0.79 | KCNA3 (0.46) | KDM4EALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL407685 | 0.77 | ALDH1A1 (0.42) | HTR6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17956279 | 0.76 | CNR2 (0.49) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL15062690 | 0.75 | IDO1 (0.39) | TDP1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL17956248 | 0.75 | CNR2 (0.51) | — | |
| SCHEMBL7232114 | 0.70 | HTR2C (0.64) | HTR6TDP1KDM4EMAPTMEN1 | |
| SCHEMBL3091133 | 0.67 | P2RX4 (0.48) | HTR6KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12614376 | 0.67 | HTR6 (0.59) | HTR6TDP1KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354348-A1 | SEMISYNTHETIC AURONES AND METHODS OF USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354348-A1 | SEMISYNTHETIC AURONES AND METHODS OF USE THEREOF | AURKA, CYP7A1, SLC7A1 | HTR6 2168/4885TDP1 1976/4885KDM4E 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.