Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623088 | 0.84 | CES1 (0.43) | MRGPRX4PARP1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL15436107 | 0.81 | NQO2 (0.48) | MRGPRX4PARP1GAAADORA2ANPSR1 | |
| SCHEMBL17922691 | 0.81 | ADORA2A (0.48) | MRGPRX4PARP1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL15865629 | 0.80 | MRGPRX4 (0.39) | MRGPRX4PARP1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL2374158 | 0.79 | KMT2A (0.46) | SMN1; SMN2NPC1RAB9AGRM5NPSR1 | |
| SCHEMBL15418113 | 0.78 | MTNR1A (0.39) | NPC1RAB9ANPSR1 | |
| SCHEMBL7170143 | 0.77 | CNR2 (0.44) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16834473 | 0.77 | MRGPRX4 (0.50) | MRGPRX4PARP1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL5269435 | 0.77 | CYP1A2 (0.50) | MRGPRX4PARP1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL16355749 | 0.77 | VSIR (0.48) | MRGPRX4PARP1MAPTCYP1A2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2025-10-28 | — | — | US | disclosed |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2023-04-13 | — | — | US | disclosed |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| EP-3966211-A1 | MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF | Janssen Biotech, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |
| CN-114127059-A | Macrocyclic chelants and methods of use thereof | 詹森生物科技公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020229974-A1 | MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | MRGPRX4 881/4885PARP1 2245/4885MAPT 2830/4885 |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | MRGPRX4 881/4885PARP1 2245/4885MAPT 2830/4885 |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | MRGPRX4 881/4885PARP1 2245/4885MAPT 2830/4885 |
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | MRGPRX4 881/4885PARP1 2245/4885MAPT 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.