Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646342 | 1.00 | TSHR (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL22653068 | 1.00 | TSHR (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL22633347 | 0.94 | TSHR (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL22633350 | 0.94 | TSHR (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL30670411 | 0.94 | TSHR (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL15119440 | 0.89 | TSHR (0.38) | TSHRMEN1KMT2A | |
| SCHEMBL14646353 | 0.89 | ALDH1A1 (0.37) | TSHRMEN1KMT2A | |
| SCHEMBL12516552 | 0.88 | TSHR (0.37) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL11780600 | 0.85 | GSR (0.36) | — | |
| SCHEMBL15043442 | 0.84 | KDM4E (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2025-10-28 | — | — | US | disclosed |
| CN-114127059-B | Macrocyclic chelators and methods of use thereof | 詹森生物科技公司 | 2024-09-24 | — | — | CN | disclosed |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2023-04-13 | — | — | US | disclosed |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| CN-114127059-A | Macrocyclic chelants and methods of use thereof | 詹森生物科技公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020229974-A1 | MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2020-11-12 | — | — | US | disclosed |
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | TSHR 225/4885MAPK1 4726/4885MEN1 173/4885 |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | TSHR 225/4885MAPK1 4726/4885MEN1 173/4885 |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | TSHR 225/4885MAPK1 4726/4885MEN1 173/4885 |
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | TSHR 225/4885MAPK1 4726/4885MEN1 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.