Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838416 | 0.97 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL29402889 | 0.97 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL29400649 | 0.85 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL112491 | 0.85 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL8294965 | 0.83 | CYP1A2 (0.43) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL4434438 | 0.82 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL4530181 | 0.82 | PTGS1 (0.42) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL8531015 | 0.82 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL29788426 | 0.82 | CYP1A2 (0.39) | CYP1A2CYP3A4PTGS1PTGS2TSHR | |
| SCHEMBL17007494 | 0.81 | HSP90AA1 (0.37) | CYP1A2CYP3A4PLGPLAUF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230111252-A1 | THIOSEMICARBAZATES AND USES THEREOF | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) | 2023-04-13 | — | — | US | disclosed |
| US-20200354318-A1 | THIOSEMICARBAZATES AND USES THEREOF | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) | 2020-11-12 | — | — | US | disclosed |
| WO-2020227592-A1 | THIOSEMICARBAZATES AND USES THEREOF | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230111252-A1 | THIOSEMICARBAZATES AND USES THEREOF | TST, ABAT, AADAC | CYP1A2 3108/4885CYP3A4 1598/4885PTGS1 4428/4885 |
| US-20200354318-A1 | THIOSEMICARBAZATES AND USES THEREOF | TST, ABAT, AADAC | CYP1A2 3108/4885CYP3A4 1598/4885PTGS1 4428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.