Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 8/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31587515 | 1.00 | VCAM1 (0.42) | VCAM1CCR2PDE7ATSHRMAPK1 | |
| SCHEMBL1625901 | 0.84 | VCAM1 (0.46) | VCAM1CCR2TSHRMAPK1ALDH1A1 | |
| SCHEMBL22636682 | 0.80 | MAPT (0.44) | VCAM1MAPK1MAPTALDH1A1MEN1 | |
| SCHEMBL29825963 | 0.80 | MAPT (0.44) | VCAM1MAPK1MAPTALDH1A1MEN1 | |
| SCHEMBL3897956 | 0.78 | PDE7A (0.53) | VCAM1PDE7ATSHRMAPK1MAPT | |
| SCHEMBL30733173 | 0.78 | PDE7A (0.53) | VCAM1PDE7ATSHRMAPK1MAPT | |
| SCHEMBL22557554 | 0.77 | CA1 (0.44) | VCAM1CCR2TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL22637083 | 0.75 | ALDH1A1 (0.49) | VCAM1PDE7ATSHRMAPK1MAPT | |
| SCHEMBL18586890 | 0.74 | ALDH1A1 (0.45) | VCAM1MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11772881 | 0.73 | ALDH1A1 (0.56) | VCAM1TSHRMAPK1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12485169-B2 | Compounds | Grey Wolf Therapeutics Limited (GB) | 2025-12-02 | — | — | US | disclosed |
| US-12377084-B2 | ERAP1 modulators | Grey Wolf Therapeutics Limited (GB) | 2025-08-05 | — | — | US | disclosed |
| US-20240366595-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| US-12023333-B2 | Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators | Grey Wolf Therapeutics Limited (GB) | 2024-07-02 | — | — | US | disclosed |
| US-12023333-B2 | Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators | Grey Wolf Therapeutics Limited (GB) | 2024-07-02 | — | — | US | disclosed |
| US-20230064417-A1 | COMPOUNDS | Grey Wolf Therapeutics Limited (GB) | 2023-03-02 | — | — | US | disclosed |
| US-20230000851-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2023-01-05 | — | — | US | disclosed |
| US-20220347176-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-11-03 | — | — | US | disclosed |
| EP-4058429-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-09-21 | — | — | EP | disclosed |
| EP-3966196-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-03-16 | — | — | EP | disclosed |
| EP-3883650-A1 | COMPOUNDS | Grey Wolf Therapeutics Limited (GB) | 2021-09-29 | — | — | EP | disclosed |
| CN-113056305-A | Compound (I) | 格雷沃尔夫治疗有限公司 | 2021-06-29 | — | — | CN | disclosed |
| WO-2021094763-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2021-05-20 | — | — | WO | disclosed |
| WO-2020225569-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366595-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | CHP1, ERAP1, QSOX1 | VCAM1 2727/4885CCR2 393/4885PDE7A 4298/4885 |
| US-20220347176-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | ERAP1, CHP1, QSOX1 | VCAM1 3011/4885CCR2 421/4885PDE7A 4348/4885 |
| US-12377084-B2 | ERAP1 modulators | ERAP1, NR1I3, HRH4 | VCAM1 3822/4885CCR2 514/4885PDE7A 3070/4885 |
| US-20230064417-A1 | COMPOUNDS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRH4, CBR3 | VCAM1 4618/4885CCR2 133/4885PDE7A 4076/4885 |
| US-12023333-B2 | Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators | ERAP1, CHP1, QSOX1 | VCAM1 2651/4885CCR2 347/4885PDE7A 4190/4885 |
| US-20230000851-A1 | ERAP1 MODULATORS | ERAP1, NR1I3, HRH4 | VCAM1 3822/4885CCR2 514/4885PDE7A 3070/4885 |
| US-12485169-B2 | Compounds | SLC10A1, VHL, CFTR | VCAM1 4004/4885CCR2 4415/4885PDE7A 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.