Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31053870 | 0.89 | ALDH1A1 (0.46) | GAAALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL16168691 | 0.79 | POLB (0.65) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29758132 | 0.79 | MAPT (0.65) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL7445704 | 0.79 | MAPT (0.65) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL996297 | 0.78 | ALDH1A1 (0.58) | GAAALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL12391448 | 0.77 | ALDH1A1 (0.52) | GAAALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL14322049 | 0.77 | MAPT (0.55) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL299335 | 0.76 | MAPT (0.65) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL15828736 | 0.76 | KMT2A (0.47) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL10066581 | 0.76 | KMT2A (0.53) | ALDH1A1KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966196-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-03-16 | — | — | EP | disclosed |
| WO-2020225569-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2020-11-12 | — | — | WO | disclosed |