Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.33 |
| ▸ | HRH1 | P35367 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23661911 | 0.85 | CYP1A2 (0.36) | ESR1ESR2NR3C2CYP2D6HRH1 | |
| SCHEMBL20285552 | 0.83 | ESR1 (0.38) | ESR1ESR2 | |
| SCHEMBL20694181 | 0.81 | NR3C2 (0.42) | NR3C2CYP2D6CYP3A4KCNH2KDM4E | |
| SCHEMBL22844051 | 0.79 | NR3C2 (0.43) | ESR1ESR2NR3C2CYP3A4KCNH2 | |
| SCHEMBL12120626 | 0.78 | GABRA1 (0.40) | NR3C2KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL24185043 | 0.77 | KDM4E (0.30) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL19227962 | 0.76 | NR3C2 (0.56) | ESR1ESR2NR3C2ALDH1A1 | |
| SCHEMBL25744955 | 0.75 | HTR2A (0.33) | NR3C2 | |
| SCHEMBL18763524 | 0.75 | ADRB2 (0.46) | NR3C2CYP2D6CYP3A4KMT2AALDH1A1 | |
| SCHEMBL25135962 | 0.75 | NR3C2 (0.36) | NR3C2CYP2D6CYP3A4KCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221803-A1 | ATF6 INHIBITORS AND USES THEREOF | ALTOS LABS, INC. | 2021-07-22 | — | — | US | disclosed |
| US-10829485-B2 | ATF6 inhibitors and uses thereof | BLACK BELT TX LTD (GB) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829485-B2 | ATF6 inhibitors and uses thereof | ATF4, XBP1, ATF1 | ESR1 776/4885ESR2 231/4885NR3C2 1808/4885 |
| US-20210221803-A1 | ATF6 INHIBITORS AND USES THEREOF | ATF4, XBP1, ATF1 | ESR1 776/4885ESR2 231/4885NR3C2 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.