Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375387 | 0.85 | SOS1 (0.38) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL1584803 | 0.84 | LTA4H (0.48) | ALDH1A1TDP1MAPTHTTL3MBTL1 | |
| SCHEMBL5583787 | 0.82 | TEAD4 (0.45) | TEAD4ALDH1A1TDP1POLBMAPT | |
| SCHEMBL21630305 | 0.81 | TEAD4 (0.44) | TEAD4ALDH1A1TDP1POLBMAPT | |
| SCHEMBL920492 | 0.81 | TEAD4 (0.44) | TEAD4ALDH1A1TDP1POLBMAPT | |
| SCHEMBL14937866 | 0.80 | SLC6A4 (0.37) | POLBMAPTARL3MBTL1PTGS2 | |
| SCHEMBL5583736 | 0.77 | AR (0.51) | TEAD4ALDH1A1TDP1POLBMAPT | |
| SCHEMBL921069 | 0.76 | TEAD4 (0.56) | TEAD4ALDH1A1TDP1POLBMAPT | |
| SCHEMBL20243511 | 0.76 | GRM5 (0.35) | TDP1CYP2C9CYP3A4 | |
| SCHEMBL83814 | 0.75 | TEAD4 (0.74) | TEAD4ALDH1A1TDP1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | claimed |