SCHEMBL5583736

SCHEMBL5583736

Cc1ccc(Oc2cc[c]c(C(F)(F)F)c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AR P10275 9/20 0.51
TEAD4 Q15561 1/20 0.40
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
HTR2A P28223 1/20 0.38
SLC6A4 P31645 1/20 0.38
KCNH2 Q12809 1/20 0.38
HTT P42858 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
MMP13 P45452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21630288 0.85 PDE4A (0.41) ARMAPTSLC6A4KCNH2L3MBTL1
SCHEMBL21630340 0.83 MAPT (0.40) ARMAPTSLC6A4
SCHEMBL21630312 0.83 AR (0.51) ARALDH1A1MAPTHTR2ASLC6A4
SCHEMBL5903665 0.83 LTA4H (0.43) AR
SCHEMBL920492 0.77 TEAD4 (0.44) ARTEAD4ALDH1A1TDP1POLB
SCHEMBL2264146 0.77 TEAD4 (0.47) ARTEAD4ALDH1A1TDP1POLB
SCHEMBL160639 0.77 PGR (0.36) ARALDH1A1TDP1MAPTL3MBTL1
SCHEMBL5583787 0.75 TEAD4 (0.45) ARTEAD4ALDH1A1TDP1POLB
SCHEMBL21630275 0.74 GRM4 (0.36) AR
SCHEMBL457652 0.74 KIF11 (0.32) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US claimed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP claimed
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed