Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20389583 | 0.85 | ALDH1A1 (0.52) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL10245176 | 0.79 | ALDH1A1 (0.53) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL51355 | 0.76 | HTT (0.58) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL15116693 | 0.75 | NPC1 (0.54) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL21058229 | 0.74 | ALDH1A1 (0.49) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL157282 | 0.74 | ALDH1A1 (0.62) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL15125214 | 0.74 | NPC1 (0.52) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL7346729 | 0.73 | ALDH1A1 (0.61) | ALDH1A1PKMNPC1RAB9AL3MBTL1 | |
| SCHEMBL121529 | 0.73 | CHRM2 (0.70) | ALDH1A1PKMGAAHTTCHRM2 | |
| SCHEMBL23160258 | 0.73 | LMNA (0.61) | ALDH1A1PKMNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3568396-B1 | NOVEL AMINO-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2020-11-11 | — | — | EP | disclosed |