Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 12/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 11/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 11/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19226817 | 0.89 | GNAO1 (0.54) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL29321999 | 0.89 | GNAO1 (0.54) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL24429368 | 0.85 | GNAI3 (0.41) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL22648543 | 0.83 | GNAO1 (0.51) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL22001246 | 0.81 | CYP1A2 (0.35) | GNAO1GNAI3GNAI1EPHX1CYP1A2 | |
| SCHEMBL19966694 | 0.81 | POLB (0.32) | EPHX1CYP1A2 | |
| SCHEMBL21214476 | 0.79 | GNAO1 (0.47) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL19226670 | 0.79 | GNAO1 (0.47) | GNAO1GNAI3GNAI1EPHX1KCNH2 | |
| SCHEMBL21166221 | 0.77 | CYP1A2 (0.42) | EPHX1CYP1A2 | |
| SCHEMBL22752273 | 0.77 | GNAO1 (0.39) | GNAO1GNAI3GNAI1EPHX1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | XBP1, RNASE1, ERN1 | GNAO1 2878/4885GNAI3 2035/4885GNAI1 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.