Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 4/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429464 | 0.86 | GNAI3 (0.49) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL19826326 | 0.84 | GNAI3 (0.46) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL18922344 | 0.82 | GNAI3 (0.53) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL13369708 | 0.81 | GNAI3 (0.46) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL20803857 | 0.81 | KDM4E (0.40) | DPP7EPHX1POLB | |
| SCHEMBL21164693 | 0.79 | KDM4E (0.43) | DPP7EPHX1POLB | |
| SCHEMBL11054211 | 0.79 | KDM4E (0.43) | DPP7EPHX1POLB | |
| SCHEMBL22648484 | 0.78 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL23139675 | 0.78 | KCNH2 (0.32) | KCNH2 | |
| SCHEMBL28514340 | 0.77 | GNAO1 (0.55) | GNAI3GNAO1GNAI1KCNH2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | XBP1, RNASE1, ERN1 | GNAI3 2035/4885GNAO1 2878/4885GNAI1 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.