Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | CCR1 | P32246 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SDCBP | O00560 | 1/20 | 0.43 |
| ▸ | SDC2 | P34741 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276321 | 0.84 | ERAP2 (0.58) | CCR1SMN1; SMN2HDAC2HDAC8HDAC6 | |
| SCHEMBL7276329 | 0.84 | ERAP2 (0.58) | CCR1SMN1; SMN2HDAC2HDAC8HDAC6 | |
| SCHEMBL6446379 | 0.82 | ALDH1A1 (0.56) | CCR1SMN1; SMN2HDAC2HDAC8HDAC6 | |
| SCHEMBL5711363 | 0.82 | ALDH1A1 (0.56) | CCR1SMN1; SMN2HDAC2HDAC8HDAC6 | |
| SCHEMBL30887591 | 0.82 | ACE (0.60) | KLK5ACECTSGCMA1ALDH1A1 | |
| SCHEMBL30291800 | 0.82 | ACE (0.60) | KLK5ACECTSGCMA1ALDH1A1 | |
| SCHEMBL2063189 | 0.81 | CASP1 (0.50) | KLK5ACEHDAC2HDAC8HDAC6 | |
| SCHEMBL27706581 | 0.81 | CASP1 (0.50) | KLK5ACEHDAC2HDAC8HDAC6 | |
| SCHEMBL20885259 | 0.80 | SYK (0.59) | KLK5 | |
| SCHEMBL11657615 | 0.80 | SYK (0.59) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354318-A1 | THIOSEMICARBAZATES AND USES THEREOF | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354318-A1 | THIOSEMICARBAZATES AND USES THEREOF | TST, ABAT, AADAC | KLK5 2003/4885CCR1 4049/4885SMN1; SMN2 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.