Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194121 | 0.76 | F2 (0.46) | S1PR3ALDH1A1S1PR4S1PR2MAPT | |
| SCHEMBL21998506 | 0.74 | ALDH1A1 (0.51) | S1PR3ALDH1A1S1PR4S1PR2MAPT | |
| SCHEMBL10298010 | 0.66 | TSHR (0.53) | ALDH1A1L3MBTL1 | |
| SCHEMBL20194125 | 0.66 | GAA (0.41) | ALDH1A1MAPTGAAKMT2AHSD17B10 | |
| SCHEMBL20194159 | 0.65 | KDM4E (0.52) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL10814700 | 0.64 | TSHR (0.54) | S1PR3ALDH1A1S1PR4MAPTKMT2A | |
| SCHEMBL27722471 | 0.62 | TSHR (0.57) | ALDH1A1MAPTGAAKMT2ASMN1; SMN2 | |
| SCHEMBL60081 | 0.62 | TSHR (0.52) | ALDH1A1MAPTKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4269304 | 0.62 | SMN1; SMN2 (0.50) | ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL12095675 | 0.62 | GAA (0.44) | ALDH1A1MAPTGAAKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |