Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650526 | 0.91 | MAP4K1 (0.44) | MYLK4STK17AIKBKBCHUKCDK1 | |
| SCHEMBL22650426 | 0.88 | IKBKB (0.42) | ACVR1IKBKBCHUKCDK1CCNB1 | |
| SCHEMBL22650939 | 0.88 | CAMK2D (0.44) | STK17AEGFRPRKCAPRKCDIKBKB | |
| SCHEMBL29491175 | 0.85 | CDK4 (0.49) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22650568 | 0.85 | CDK4 (0.49) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22650937 | 0.84 | CDK4 (0.40) | MYLK4STK17AEGFRCDK1CCNB1 | |
| SCHEMBL22650432 | 0.83 | CDK6 (0.35) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL22650524 | 0.83 | CDK6 (0.38) | MYLK4STK17AEGFRIKBKBCHUK | |
| SCHEMBL22650940 | 0.82 | BTK (0.38) | MYLK4STK17ACLK4TBK1ZAP70 | |
| SCHEMBL22650485 | 0.81 | CDK4 (0.47) | CDK1CCNB1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |