Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.40 |
| ▸ | CCND1 | P24385 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | LDLR | P01130 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650524 | 0.92 | CDK6 (0.38) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650526 | 0.89 | MAP4K1 (0.44) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650568 | 0.88 | CDK4 (0.49) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL29491175 | 0.88 | CDK4 (0.49) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650939 | 0.87 | CAMK2D (0.44) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650432 | 0.86 | CDK6 (0.35) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650430 | 0.84 | MYLK4 (0.43) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650485 | 0.84 | CDK4 (0.47) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650426 | 0.81 | IKBKB (0.42) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL22650522 | 0.80 | F10 (0.37) | CDK4CCND1CDK1CCNB1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |