Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650461 | 0.92 | MAP3K14 (0.47) | MAP3K14JAK2JAK1JAK3TBK1 | |
| SCHEMBL22650489 | 0.86 | MAP3K14 (0.48) | MAP3K14CDK2TBK1ACVR1 | |
| SCHEMBL22650849 | 0.76 | CDK1 (0.47) | CDK2JAK2JAK1JAK3DYRK2 | |
| SCHEMBL22650848 | 0.74 | CDK1 (0.49) | CDK2JAK2JAK1JAK3BTK | |
| SCHEMBL22650936 | 0.74 | IKBKE (0.48) | MAP3K14JAK2JAK1JAK3MAPK1 | |
| SCHEMBL22650851 | 0.74 | IKBKB (0.56) | CDK2 | |
| SCHEMBL22650921 | 0.73 | MTOR (0.49) | CDK2DYRK2 | |
| SCHEMBL22650925 | 0.73 | CDK2 (0.61) | CDK2KCNH2JAK1ACVR1 | |
| SCHEMBL22650923 | 0.72 | MAPK8 (0.54) | CDK2KCNH2JAK2ACVR1 | |
| SCHEMBL22650920 | 0.71 | CDK2 (0.54) | CDK2KCNH2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |