Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | NEK3 | P51956 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650920 | 0.90 | CDK2 (0.54) | MAPK8MAPK10CDK2KCNH2CDK4 | |
| SCHEMBL22650919 | 0.89 | CDK2 (0.54) | MAPK8MAPK10CDK2KCNH2GSK3B | |
| SCHEMBL22650921 | 0.87 | MTOR (0.49) | CDK2CDK4IKBKBCHUKCDK1 | |
| SCHEMBL22650796 | 0.85 | CDK2 (0.44) | CDK2KCNH2CDK4JAK2IKBKB | |
| SCHEMBL22650918 | 0.85 | DKK1 (0.57) | MAPK8MAPK10CDK2GSK3BJAK2 | |
| SCHEMBL22650849 | 0.85 | CDK1 (0.47) | CDK2JAK2IKBKBCHUKCDK1 | |
| SCHEMBL22650927 | 0.84 | CDK2 (0.52) | CDK2KCNH2CDK4IKBKBCHUK | |
| SCHEMBL22650800 | 0.83 | IKBKB (0.46) | CDK2KCNH2CDK4JAK2IKBKB | |
| SCHEMBL22650848 | 0.83 | CDK1 (0.49) | CDK2JAK2IKBKBCHUKACVR1 | |
| SCHEMBL22650851 | 0.82 | IKBKB (0.56) | CDK2IKBKBCHUKCDK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |